BDH1 Mouse Monoclonal Antibody [C3-A5]
Catalog# EM1709-15
BDH1 Mouse Monoclonal Antibody [C3-A5]
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WB
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IHC-P
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Human
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Mouse
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unconjugated
概述
产品名称
BDH1 Mouse Monoclonal Antibody [C3-A5]
抗体类型
Mouse Monoclonal Antibody
免疫原
Recombinant protein
种属反应性
Human, Mouse
验证应用
WB, IHC-P
分子量
45 kDa
阳性对照
HepG2, NIH/3T3 cell lysate, human prostate tissue, human colorectal cancer tissue, human liver cancer tissue.
偶联
unconjugated
克隆号
C3-A5
产品特性
形态
Liquid
浓度
存放说明
4℃; -20℃ for long term storage.
存储缓冲液
Purified antibody in PBS with 0.05% sodium azide.
亚型
IgG1
纯化方式
Protein A affinity purified.
应用稀释度
-
WB
-
1:500-1:1,000
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IHC-P
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1:50-1:200
靶点
功能
BDH1 (3-hydroxybutyrate dehydrogenase, type 1), also known as BDH or SDR9C1, is a 343 amino acid protein that localizes to the mitochondrial matrix and belongs to the short-chain dehydrogenases/reductases (SDR) family. Existing as a homotetramer, BDH1 functions to catalyze the NAD+-dependent interconversion of (R)-3-hydroxybutanoate and acetoacetate, a reaction that is allosterically activated by phosphatidylcholine. As both (R)-3-hydroxybutanoate and acetoacetate are two major ketone bodies produced during fatty acid catabolism, BDH1 plays an important role in the metabolic degradation of fatty acids. The gene encoding BDH1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.
背景文献
1. Loeb-Hennard C et al. (R)-3-hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domain. Biochemistry. 2000 Oct 3;39(39):11928-38.
2. Xu XR et al. Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15089-94.
亚细胞定位
Mitochondrion matrix.
别名
3 hydroxybutyrate dehydrogenase (heart
mitochondrial) antibody
3-hydroxybutyrate dehydrogenase antibody
BDH antibody
BDH_HUMAN antibody
BDH1 antibody
D beta hydroxybutyrate dehydrogenase
mitochondrial antibody
D-beta-hydroxybutyrate dehydrogenase antibody
mitochondrial antibody
图片
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Western blot analysis of BDH1 on HepG2 and NIH/3T3 cell lysate using anti-BDH1 antibody at 1/1,000 dilution.
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Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-BDH1 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human colorectal cancer tissue using anti-BDH1 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-BDH1 antibody. Counter stained with hematoxylin.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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