Apolipoprotein A1 Mouse Monoclonal Antibody

功能

Apolipoprotein AI (Apo-AI) is a protein that in humans is encoded by the APOA1 gene. As the major component of high-density lipoprotein (HDL) particles, it has a specific role in lipid metabolism. Apolipoprotein AI is the major protein component of high density lipoprotein (HDL) particles in plasma. Chylomicrons secreted from the intestinal enterocyte also contain Apo-AI, but it is quickly transferred to HDL in the bloodstream. The protein, as a component of HDL particles, enables efflux of fat molecules by accepting fats from within cells (including macrophages within the walls of arteries which have become overloaded with ingested fats from oxidized low-density lipoprotein (LDL) particles) for transport (in the water outside cells) elsewhere, including back to LDL particles or to the liver for excretion.

背景文献

1. "Gene structure of human apolipoprotein A1."Shoulders C.C., Kornblihtt A.R., Munro B.S., Baralle F.E.Nucleic Acids Res. 11:2827-2837(1983)

2. "The preferential site of non-enzymatic glycation of human apolipoprotein A-I in vivo."Calvo C., Ulloa N., Campos M., Verdugo C., Ayrault-Jarrier M.Clin. Chim. Acta 217:193-198(1993)

3. "Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins." Niederkofler E.E., Tubbs K.A., Kiernan U.A., Nedelkov D., Nelson R.W.J. Lipid Res. 44:630-639(2003)

序列相似性

Belongs to the apolipoprotein A1/A4/E family.

组织特异性

Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.

翻译后修饰

Glycosylated.; Palmitoylated.; Phosphorylation sites are present in the extracellular medium.

亚细胞定位

Secreted.

UNIPROT

SwissProt: P02647 Human

别名