RUNX2 Rabbit Polyclonal Antibody
Rmb: 618 特惠 1500
Catalog# ER1802-78
RUNX2 Rabbit Polyclonal Antibody
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WB
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IHC-P
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IF-Cell
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Human
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unconjugated
概述
产品名称
RUNX2 Rabbit Polyclonal Antibody
抗体类型
Rabbit Polyclonal Antibody
免疫原
Synthetic peptide of C-terminal human RUNX2.
种属反应性
Human
验证应用
WB, IHC-P, IF-Cell
分子量
Predicted band size: 57 kDa
阳性对照
HL-60 cell lysate, A431, human tonsil tissue, human colon tissue.
偶联
unconjugated
RRID
产品特性
形态
Liquid
浓度
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
存储缓冲液
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG
纯化方式
Immunogen affinity purified.
应用稀释度
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WB
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1:500
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IF-Cell
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1:50-1:200
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IHC-P
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1:50-1:200
靶点
功能
The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2αB, CBFA2), RUNX2 (also designated AML-3, PEBP2αA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPαC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature.
背景文献
暂无
组织特异性
Specifically expressed in osteoblasts.
翻译后修饰
Phosphorylated; probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation (By similarity). Phosphorylation at Ser-451 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression. Isoform 3 is phosphorylated on Ser-340.
亚细胞定位
Nucleus.
UNIPROT
别名
Acute myeloid leukemia 3 protein antibody
Alpha subunit 1 antibody
AML3 antibody
CBF alpha 1 antibody
CBF-alpha-1 antibody
CBFA1 antibody
CCD antibody
CCD1 antibody
Cleidocranial dysplasia 1 antibody
Core binding factor antibody
展开图片
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Western blot analysis of RUNX2 on HL-60 cell lysate using anti-RUNX2 antibody at 1/500 dilution.
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ICC staining RUNX2 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
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Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-RUNX2 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-RUNX2 antibody. Counter stained with hematoxylin.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
引文
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Secreted Frizzled‐Related Protein 2 Promotes Osteogenic Differentiation and Bone Regeneration in Perthes Disease When Targeted by miR‐106a‐5p
期刊: Journal Of Cellular And Molecular Medicine
DOI: 10.1111/jcmm.70804
IF: 4.2
应用: WB
反应种属: Rabbit
发表时间: 2025 Sept
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Impact of intercellular adhesion molecule 1-positive dental pulp stem cells in deep caries progression
期刊: International endodontic journal
DOI: 10.1111/iej.14248
IF: 5.4
应用: WB
反应种属: Human
发表时间: 2025 May
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A Novel DSPP Mutation in Dentinogenesis Imperfecta Shields Type II: Clinical, Genetic and Stem Cell Perspectives
期刊: INTERNATIONAL DENTAL JOURNAL
DOI: 10.1016/j.identj.2025.100937
IF: 3.7
应用: WB
反应种属: Human
发表时间: 2025 Aug
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LATS1/YAP1 Axis Controls Bone Regeneration on Distraction Osteogenesis by Activating Wnt/β-catenin
期刊: Tissue Engineering Part A
DOI:
IF: 4.1
应用: WB
反应种属: Rat
发表时间: 2023 Nov
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