CD4 Rabbit Polyclonal Antibody

功能

The CD4 gene encodes the T4 antigen, a glycoprotein of approximately 55 kDa, expressed on the surface of helper T lymphocytes.CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in major histocompatibility complex class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as interleukin-15 receptors and bind to the HIV receptors, binding directly to the HIV envelope protein GP120.

背景文献

1. Parnes J.R., Hunkapiller T.; "L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system."; Immunol. Rev. 100:109-127(1987).

2. Gorman S.D., Tourvieille B., Parnes J.R.; "Structure of the mouse gene encoding CD4 and an unusual transcript in brain.";Proc. Natl. Acad. Sci. U.S.A. 84:7644-7648(1987).

3. Rudd CE.CD4,CD8and the TCR-CD3complex:a novel class of proˉtein-tyrosine kinase receptor.Immunol Today,1990,11(11):400-406.

组织特异性

Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.

翻译后修饰

Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.; Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization.

亚细胞定位

Cell membrane

UNIPROT #

SwissProt: P01730 Human

别名