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Anti-ACE2 antibody [SN0754]

重组兔单抗 | 货号: ET1611-58


规格:
价格:RMB   2500
  • 概述

  • 产品描述 Angiotensin-converting enzyme (ACE) is a carboxyl-terminal dipeptidyl exopeptidase that converts angiotensin I to the potent vasopressive hormone, angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in blood pressure regulation and fluid/electrolyte homeostasis. ACE2 is the first known human homolog of ACE. Unlike ACE, which is expressed ubiquitously throughout the vasculature, ACE2 is expressed only in cardiac, renal and testicular cells.
  • 产品名称 Anti-ACE2 antibody [SN0754]
  • 分子量 92 kDa
  • 种属反应性 Human, Mouse, Rat, Hamster
  • 验证应用 WB, ICC, IHC-P, IP
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within Human ACE2 aa 200-230.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A purified.
  • 亚细胞定位 Secreted, Cell membrane, Cytoplasm.
  • 数据链接 SwissProt: Q9BYF1 Human
    SwissProt: Q8R0I0 Mouse
    SwissProt: Q5EGZ1 Rat
    SwissProt: A0A1U7QTA1 Hamster
  • 其它名称 ACE 2 antibody
    ACE related carboxypeptidase antibody
    ACE-related carboxypeptidase antibody
    ACE2 antibody
    ACE2_HUMAN antibody
    ACEH antibody
    Angiotensin converting enzyme 2 antibody
    Angiotensin converting enzyme homolog antibody
    Angiotensin converting enzyme like protein antibody
    Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2 antibody
    Angiotensin I converting enzyme 2 antibody
    Angiotensin-converting enzyme homolog antibody
    DKFZP434A014 antibody
    EC 3.4.17 antibody
    metalloprotease MPROT 15 antibody
    Metalloprotease MPROT15 antibody
    OTTHUMP00000022963 antibody
    Processed angiotensin-converting enzyme 2 antibody
  • 应用

    WB: 1:1,000-1:5,000
    ICC: 1:100-1:500
    IHC-P: 1:50-1:200

  • 背景文献

  • 1. Thatcher SE et al. Angiotensin-Converting Enzyme 2 Decreases Formation and Severity of Angiotensin II-Induced Abdominal Aortic Aneurysms. Arterioscler Thromb Vasc Biol 34:2617-23 (2014).

    2. Honorato-Sampaio K et al. Evidence that angiotensin-(1-7) is an intermediate of gonadotrophin-induced oocyte maturation in the rat preovulatory follicle. Exp Physiol 97:642-50 (2012).
  • Publishing research using Anti-ACE2 antibody? Please let us know so that we can cite the reference in this datasheet.

  • Liu, J., Chen, Q., Liu, S., Yang, X., Zhang, Y., & Huang, F. (2018). Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis. Life Sci, 208, 139-148. PMID:29990483

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols