Angiotensin-converting enzyme (ACE) is a carboxyl-terminal dipeptidyl exopeptidase that converts angiotensin I to the potent vasopressive hormone, angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in blood pressure regulation and fluid/electrolyte homeostasis. ACE2 is the first known human homolog of ACE. Unlike ACE, which is expressed ubiquitously throughout the vasculature, ACE2 is expressed only in cardiac, renal and testicular cells.
Human, Mouse, Rat, Hamster
WB, ICC, IHC-P, IP
Synthetic peptide within Human ACE2 aa 200-230.
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Secreted, Cell membrane, Cytoplasm.
SwissProt: Q9BYF1 Human
SwissProt: Q8R0I0 Mouse
SwissProt: Q5EGZ1 Rat
SwissProt: A0A1U7QTA1 Hamster
ACE 2 antibody
ACE related carboxypeptidase antibody
ACE-related carboxypeptidase antibody
Angiotensin converting enzyme 2 antibody
Angiotensin converting enzyme homolog antibody
Angiotensin converting enzyme like protein antibody
Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2 antibody
Angiotensin I converting enzyme 2 antibody
Angiotensin-converting enzyme homolog antibody
EC 3.4.17 antibody
metalloprotease MPROT 15 antibody
Metalloprotease MPROT15 antibody
Processed angiotensin-converting enzyme 2 antibody
Fig1: Western blot analysis of ACE2 on human kidney lysates using anti-ACE2 antibody at 1/1,000 dilution.
Fig2: Western blot analysis of ACE2 on Hamster testis (1) and stomach (2) tissue lysates using anti-ACE2 antibody at 1/1,000 dilution.
Fig3: ICC staining ACE2 in 293 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: ICC staining ACE2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig5: ICC staining ACE2 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig6: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ACE2 antibody. Counter stained with hematoxylin.
Fig7: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-ACE2 antibody. Counter stained with hematoxylin.
Fig8: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-ACE2 antibody. Counter stained with hematoxylin.
1. Thatcher SE et al. Angiotensin-Converting Enzyme 2 Decreases Formation and Severity of Angiotensin II-Induced Abdominal Aortic Aneurysms. Arterioscler Thromb Vasc Biol 34:2617-23 (2014).
2. Honorato-Sampaio K et al. Evidence that angiotensin-(1-7) is an intermediate of gonadotrophin-induced oocyte maturation in the rat preovulatory follicle. Exp Physiol 97:642-50 (2012).
Publishing research using Anti-ACE2 antibody? Please let us know so
that we can cite the reference in this datasheet.
Liu, J., Chen, Q., Liu, S., Yang, X., Zhang, Y., & Huang, F. (2018). Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis. Life Sci, 208, 139-148.
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