IP3 Receptor Rabbit Polyclonal Antibody

功能

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

背景文献

1. Gerber S et al. Recessive and dominant de novo ITPR1 mutations cause Gillespie syndrome. Am J Hum Genet 98:971-980 (2016).

2. McEntagart M et al. A restricted repertoire of de novo mutations in ITPR1 cause Gillespie syndrome with evidence for dominant-negative effect. Am J Hum Genet 98:981-992 (2016).

序列相似性

Belongs to the InsP3 receptor family.

组织特异性

Widely expressed.

翻译后修饰

Phosphorylated on tyrosine residues.; Ubiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked (By similarity).; Phosphorylated by cAMP kinase (PKA). Phosphorylation prevents the ligand-induced opening of the calcium channels. Phosphorylation by PKA increases the interaction with inositol 1,4,5-trisphosphate and decreases the interaction with AHCYL1.; Palmitoylated by ZDHHC6 in immune cells, leading to regulate ITPR1 stability and function.

亚细胞定位

Cytoplasm. Cytoplasmic vesicle. Endoplasmic reticulum. Membrane.

UNIPROT #

SwissProt: Q14643 Human

SwissProt: P11881 Mouse

SwissProt: P29994 Rat

别名