CD14 Rabbit Polyclonal Antibody

功能

CD14 is a glycophosphatidylinositol-anchored protein expressed on the surfaces of monocytes and plymorphonuclear leukocytes. It cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). CD14 acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response and up-regulates cell surface molecules, including adhesion molecules.

背景文献

1. "Crystal structure of CD14 and its implications for lipopolysaccharide signaling."Kim J.I., Lee C.J., Jin M.S., Lee C.H., Paik S.G., Lee H., Lee J.O.J. Biol. Chem. 280:11347-11351(2005)

2. "The phagosomal proteome in interferon-gamma-activated macrophages."Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.Immunity 30:143-154(2009)

组织特异性

Detected on macrophages (at protein level). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

翻译后修饰

N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

亚细胞定位

Cell membrane, Golgi apparatus , Secreted.

UNIPROT #

SwissProt: P08571 Human

SwissProt: P10810 Mouse

别名