Beta-2 Microglobulin Rabbit Polyclonal Antibody

功能

β2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on almost all cells of the body. β-2-Microglobulin associates with the α heavy chain of MHC and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.

背景文献

1. Wani M.A., Haynes L.D., Kim J., Bronson C.L., Chaudhury C., Mohanty S., Waldmann T.A., Robinson J.M., Anderson C.L.;"Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.";Proc. Natl. Acad. Sci. U.S.A. 103:5084-5089(2006).

2. Okon M., Bray P., Vucelic D.;"1H NMR assignments and secondary structure of human beta 2-microglobulin in solution.";Biochemistry 31:8906-8915(1992).

3. Momoi T., Suzuki M., Titani K., Hisanaga S., Ogawa H., Saito A.;"Amino acid sequence of a modified beta 2-microglobulin in renal failure patient urine and long-term dialysis patient blood.";Clin. Chim. Acta 236:135-144(1995).

序列相似性

Belongs to the beta-2-microglobulin family.

翻译后修饰

Glycation of Ile-21 is observed in long-term hemodialysis patients.

亚细胞定位

Secreted.

UNIPROT #

SwissProt: P61769 Human

别名

B2M antibody

B2MG_HUMAN antibody

Beta 2 microglobin antibody

Beta 2 microglobulin antibody

Beta 2 microglobulin precursor antibody

Beta chain of mhc class 1 proteins antibody

Beta chain of MHC class I molecules antibody

Beta-2-microglobulin form pI 5.3 antibody

CDABP0092 antibody

Hdcma22p antibody