Alpha-Synuclein Mouse Monoclonal Antibody [2G5]
Catalog# RT1036
Alpha-Synuclein Mouse Monoclonal Antibody [2G5]
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WB
-
IP
-
IF
-
Human
概述
产品名称
Alpha-Synuclein Mouse Monoclonal Antibody [2G5]
抗体类型
Mouse Monoclonal Antibody
免疫原
peptide
种属反应性
Human
验证应用
WB, IP, IF
分子量
19 kDa
阳性对照
293T, SH-SY5Y.
偶联
unconjugated
克隆号
2G5
产品特性
形态
Liquid
浓度
2ug/ul
存放说明
Store at +4℃
存储缓冲液
1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
亚型
IgG1
纯化方式
Protein A affinity purified.
应用稀释度
-
WB
-
1
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100-1:1,000
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IP
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1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
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IF
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1:50-500
靶点
功能
The synuclein family members, including ?-synuclein (also designated NACP for non-∫-Amyloid component) and ∫-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. ?-synuclein is localized to neuronal cell bodies and synapses. ?-synuclein was first identified as a component of Alzheimer’s disease amyloid plaques. Abnormal platelet function in Alzheimer’s disease has been demonstrated. During megakaryocytic differentiation ?-synuclein has been found to be upregulated, while ∫-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of ?-synuclein has been found in patients with early onset Parkinson’s disease.
背景文献
1. Jin, H., et al. 2011. α-synuclein negatively regulates protein kinase Cδδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. J. Neurosci. 31: 2035-2051.
2. Ballard, C., et al. 2010. α-synuclein antibodies recognize a protein present at lower levels in the CSF of patients with dementia with Lewy bodies. Int. Psychogeriatr. 22: 321-327.
亚细胞定位
CytoplasmM embrane, Nucleus, Secreted
UNIPROT #
别名
Alpha synuclein antibody
Alpha-synuclein antibody
Alpha-synuclein
isoform NACP140 antibody
alphaSYN antibody
MGC105443 antibody
MGC110988 antibody
MGC127560 antibody
MGC64356 antibody
NACP antibody
展开图片
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Western blot analysis of α-synuclein expression in non-transfected (A) and human α-synuclein transfected (B)293T whole cell lysates.
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Western blot analysis of α-synuclein expression in SH-SY5Y whole cell lysate.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Alternative Products
Alpha-Synuclein Recombinant Rabbit Monoclonal Antibody [JB42-33]
Application: WB,IF-Cell,IF-Tissue,IHC-P,IP,FC
Reactivity: Human
Conjugate: unconjugated
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