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Anti-PI 3 Kinase p85 alpha Recombinant Mouse Monoclonal Antibody [A3-D0-R]

重组鼠单抗 | 货号: HA601206


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价格:RMB   1500
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  • 概述

  • 产品描述 Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of (p85) and (p110) subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110δ expression is restricted to white blood cells. It has been shown to bind p85α and γ, but it apparently does not phosphorylate these subunits. p110δ seems to have the capacity to autophosphorylate. p110γ does not interact with the p85 subunits. It has been shown to be activated by α and βγ heterotrimeric G proteins.
  • 产品名称 Anti-PI 3 Kinase p85 alpha Recombinant Mouse Monoclonal Antibody [A3-D0-R]
  • 分子量 Predicted band size: 84 kDa
  • 种属反应性 Human
  • 验证应用 WB,IF-Cell
  • 抗体类型 重组鼠单抗
  • 免疫原 Recombinant protein within Human PI3-kinase p85 subunit alpha aa 19-219 / 724.
  • 偶联 Non-conjugated
  • RRID AB_3071925
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG1
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cytosol, Membrane, Nucleus.
  • 数据链接 SwissProt: P27986 Human
  • 其它名称
    • GRB1 antibody
    • p85 alpha antibody
    • p85 antibody
  • 应用

    WB: 1:1,000-1:5,000
    IF-Cell: 1:100

  • 背景文献

  • 1. Hu J et al. Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling. PLoS One 9:e89352 (2014).

    2. Schmidt JW et al. Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol Cell Biol 34:1363-77 (2014).
  • Publishing research using Anti-PI 3 Kinase p85 alpha Recombinant Mouse Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols