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Anti-AKT2 Rabbit Polyclonal Antibody

兔多抗 | 货号: HA500091


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价格:RMB   1500
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  • 概述

  • 产品描述 AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake.
  • 产品名称 Anti-AKT2 Rabbit Polyclonal Antibody
  • 分子量 Predicted band size: 56 kDa.
  • 种属反应性 Human,Mouse,Rat
  • 验证应用 WB,IHC-P
  • 抗体类型 兔多抗
  • 免疫原 Synthetic peptide within C-terminal human AKT2.
  • 偶联 Non-conjugated
  • RRID AB_3071190
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Immunogen affinity purified.
  • 亚细胞定位 Nucleus, Cell membrane, Early endosome, Cytoplasm.
  • 数据链接 SwissProt: P31751 Human
    SwissProt: Q60823 Mouse
    SwissProt: P47197 Rat
  • 其它名称
    • Akt2 antibody
    • AKT2_HUMAN antibody
    • HIHGHH antibody
  • 应用

    WB: 1:500-1:1,000
    IHC-P: 1:100-1:500

  • 背景文献

  • 1. Wang S. et. al. Double knockout of Akt2 and AMPK predisposes cardiac aging without affecting lifespan: Role of autophagy and mitophagy. Biochim Biophys Acta Mol Basis Dis. 2019 Jul

    2. Sanchez-Gurmaches J. et. al. Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis. Cell Metab. 2018 Jan
  • Publishing research using Anti-AKT2 Rabbit Polyclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols