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Immunology - Immune Checkpoint

免疫检查点是免疫应答过程中调节T细胞受体(TCR)抗原识别的一种信号,可以分为以下两类:(1)共刺激免疫检查点:促进免疫进程,如CD28、ICOS、CD137;(2)共抑制免疫检查点:抑制免疫进程,如PD1、CTLA-4、VISTA等。当免疫系统攻击病原体时,这些免疫检查点分子可以保护正常组织免受侵害。癌细胞通过使免疫检查点相关蛋白失调而巧妙地逃避免疫攻击。免疫检查点疗法通过共刺激信号的激动剂或抑制信号的拮抗剂调节免疫系统功能。

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