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Epigenetics and Nuclear Signaling - Chromatin Binding Proteins

染色质结合蛋白是一类可以与染色质结合并发挥表观调控作用的蛋白,包含识别和结合表观遗传修饰的特定结构域。按照表观调控功能的不同可以分为写入者(writers),读取者(readers)和擦除者(erasers)三种。狭义的染色质结合蛋白特指读取者readers,在结构上通常存在一个腔或表面沟槽,当其修饰氨基酸的侧翼序列之间相互作用时容纳特定的表观遗传标记。

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