Cancer - Cancer Metabolism
肿瘤细胞有别于正常细胞,需要通过各种代谢途径自主改变通量,以满足增加的生物能量和生物合成需求,并减轻肿瘤细胞增殖和存活所需的氧化应激。肿瘤细胞的核酸代谢,蛋白质代谢,糖代谢都要高于正常细胞,可能由于肿瘤微环境整体呈现出缺氧的特点,即使在氧充足的条件下,肿瘤细胞仍偏好采用糖酵解的方式进行葡萄糖代谢,而不是用线粒体氧化磷酸化来产生更多的ATP,因此肿瘤细胞的葡萄糖摄取量远远高于正常细胞。
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