XPC Mouse Monoclonal Antibody
Catalog# EM1712-46
XPC Mouse Monoclonal Antibody
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WB
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IHC
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IF
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FC
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Human
概述
产品名称
XPC Mouse Monoclonal Antibody
抗体类型
Mouse Monoclonal Antibody
免疫原
Purified recombinant fragment of human XPC (AA: 32-133) expressed in mammalian.
种属反应性
Human
验证应用
WB, IHC, IF, FC
分子量
106 kDa
偶联
unconjugated
产品特性
形态
Liquid
存放说明
Store at 4℃ short term. Aliquot and store at -20℃ long term. Avoid freeze/thaw cycles.
存储缓冲液
Purified antibody in PBS with 0.05% sodium azide
亚型
IgG1
应用稀释度
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WB
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1:500 - 1:2,000
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IHC
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1:200 - 1:1,000
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IF
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1:50 - 1:200
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FC
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1:200 - 1:400
靶点
功能
The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
背景文献
暂无
亚细胞定位
Nucleus, Chromosome, Cytoplasm
UNIPROT
图片
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Western blot analysis using XPC mouse mAb against Jurkat (1) and Hela (2) cell lysate.
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Immunofluorescence analysis of Hela cells using XPC mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
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Flow cytometric analysis of Hela cells using XPC mouse mAb (green) and negative control (red).
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Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using XPC mouse mAb with DAB staining.
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Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using XPC mouse mAb with DAB staining.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"