TAL1 / SCL LS-C182473 Mouse Monoclonal Antibody [4G1]
Catalog# RT1605
TAL1 / SCL LS-C182473 Mouse Monoclonal Antibody [4G1]
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WB
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IP
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IF
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Human
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Mouse
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Rat
概述
产品名称
TAL1 / SCL LS-C182473 Mouse Monoclonal Antibody [4G1]
抗体类型
Mouse Monoclonal Antibody
免疫原
peptide
种属反应性
Human, Mouse, Rat
验证应用
WB, IP, IF
分子量
42kDa
阳性对照
293T, CCRF-CEM, Jurkat, K-562
偶联
unconjugated
克隆号
4G1
产品特性
形态
Liquid
浓度
2ug/ul
存放说明
Store at +4℃
存储缓冲液
1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
亚型
IgG1
纯化方式
Protein A affinity purified.
应用稀释度
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WB
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1:100-1:1,000
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IP
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1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
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IF
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1:50-1:500
发表文章中的应用
| WB | 查看 1 篇文献如下 |
发表文章中的种属
| Human | 查看 1 篇文献如下 |
靶点
功能
Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic coexpression of TAL1 and the catalytic subunit of casein kinase IIα, a serine/ threonine protein kinase known to modulate the activity of other βHLH transcription factors.
背景文献
1. Huang, S. and Brandt, S.J. 2000. mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor. Mol. Cell. Biol. 20: 2248-2259.
2. Kelliher, M.A., et al. 1996. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIα. EMBO J. 15: 5160-5166.
亚细胞定位
Nucleus
UNIPROT
别名
bHLHa17 antibody
Class A basic helix-loop-helix protein 17 antibody
OTTHUMP00000009563 antibody
OTTHUMP00000009564 antibody
SCL antibody
STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR antibody
Stem cell protein antibody
T cell acute lymphocytic leukemia 1 antibody
T cell acute lymphocytic leukemia 1 protein antibody
T cell acute lymphocytic leukemia 1 protein antibody
展开图片
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Western blot analysis of TAL1 expression in non-transfected (A) and human TAL1 transfected (B) 293T whole cell lysates and CCRF-CEM (C), Jurkat (D) and K-562 (E) nuclear extracts.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
引文
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TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN
Author: Qiu, Q., Sun, Y., Yang, L., Li, Q., Feng, Y., Li, M., Yin, Y., Zheng, L., Li, N., Qiu, H., Cui, X., He, W., Wang, B., Pan, C., Wang, Z., Huang, J., Sample, K. M., Li, Z., & Hu, Y.
PMID: 36854750
应用: WB
反应种属: Human
发表时间: 2023 Mar
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Citation