MASP2 Mouse Monoclonal Antibody [F3-4]

功能

Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene. MASP-2 involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.

背景文献

1. "The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions." Harmat V., Gal P., Kardos J., Szilagyi K., Ambrus G., Vegh B., Naray-Szabo G., Zavodszky P. J. Mol. Biol. 342:1533-1546(2004)

2. "A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations." Gal P., Harmat V., Kocsis A., Bian T., Barna L., Ambrus G., Vegh B., Balczer J., Sim R.B., Naray-Szabo G., Zavodszky P. J. Biol. Chem. 280:33435-33444(2005)

3. "Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms." Thiel S., Steffensen R., Christensen I.J., Ip W.K., Lau Y.L., Reason I.J., Eiberg H., Gadjeva M., Ruseva M., Jensenius J.C. Genes Immun. 8:154-163(2007)

序列相似性

Belongs to the ku70 family.

翻译后修饰

Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.; ADP-ribosylated by PARP3.

亚细胞定位

Secreted

UNIPROT

SwissProt: O00187 Human

别名

Mannan binding lectin serine peptidase 2 antibody

Mannan binding lectin serine protease 2 antibody

Mannose binding protein associated serine protease 2 antibody

MAP 19 antibody

MAP19 antibody

MASP 2 antibody

MBL associated plasma protein of 19 kD antibody

MBL associated serine protease 2 antibody

Small MBL associated protein antibody

sMAP antibody