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Human TNFR2/CD120b/TNFRSF1B Protein

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Catalog# HA210176

Human TNFR2/CD120b/TNFRSF1B Protein

Product Information

Product name

Human TNFR2/CD120b/TNFRSF1B Protein

Catalog No.

HA210176

Predicted molecular mass

The protein has a predicted MW of 26.2 kDa. Due to glycosylation, the protein migrates to 48-60 kDa based on Tris-Bis PAGE result.

Protein construction description

Recombinant Human TNFR2/CD120b/TNFRSF1B Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Leu23-Asp257.[Accession | P20333-1]

Accession

P20333-1

Source

HEK293

Purity

> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC

Endotoxin

Less than 1EU per μg by the LAL method.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Species

Human

Background

Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Usage guide

Storage

-20 to -80℃ for 12 months as supplied from date of receipt. -80℃ for 3-6 months after reconstitution. 2-8℃ for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.