HLA E Mouse Monoclonal Antibody [4G23]

功能

Major histocompatibility complex (MHC) molecules, which include human leukocyte antigens (HLAs), form an integral part of the immune response system. They are cell surface receptors that bind foreign peptides and present them to cytotoxic T lymphocytes (CTLs). MHC class I molecules consist of two polypeptide chains, an α or heavy chain and a non-covalently associated pro- tein, β-2-Microglobulin. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-A is a MHC class I heavy chain molecule that plays a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and HLA-C are proteins encod- ed by closely related genes that also exist in the MHC class I. HLA-E belongs to the HLA class I heavy chain paralog. HLA-E is a heterodimer consisting of a heavy chain and a light chain; the heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules.

背景文献

1. Ishitani, A., et al. 2006. The involvement of HLA-E and -F in pregnancy. J. Reprod. Immunol. 69: 101-113.

2. Lajoie, J., et al. 2006. Genetic variants in nonclassical major histocompati- bility complex class I human leukocyte antigen HLA-E and HLA-G molecules are associated with susceptibility to heterosexual acquisition of HIV-1. J. Infect. Dis. 193: 298-301.

亚细胞定位

Membrane

UNIPROT

SwissProt: P13747 Human

别名