PGAM1 Recombinant Rabbit Monoclonal Antibody [JE40-67]

功能

Members of the PGAM (phosphoglycerate mutase) family of proteins are important components of glucose and 2,3-BPGA (2,3-bisphosphoglycerate) metabolism. They are responsible for catalyzing the transfer of phospho groups between the carbon atoms of phosphoglycerates. In mammals there are two types of PGAM isozymes: PGAM1 (also known as PGAMB) and PGAM2 (also known as PGAMA). In the cell, PGAM1 and PGAM2 exist as either homodimers or heterodimers and are responsible for the interconversion of 3-phosphoglycerate and 2-phosphoglycerate. PGAM2 homodimers are expressed in skeletal muscle, mature sperm cells and heart; PGAM1 homodimers are found in most other tissues; and PGAM1/PGAM2 heterodimers are found exclusively in the heart. PGAM4, also known as PGAM3, is a protein formerly considered to be specific to humans. Initially the PGAM4 gene was described as a pseudogene but it is now known to encode a functional protein at least 25 million years old. The gene encoding PGAM4 is believed to have originated by retrotransposition, with the original copy being the PGAM1 gene.

背景文献

1. Wang Y et al. Crystal structure of human B-type phosphoglycerate mutase bound with citrate. Biochem Biophys Res Commun 331:1207-1215 (2005).

2. Hitosugi T et al. Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nat Commun 4:1790-1790 (2013).

序列相似性

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

组织特异性

Expressed in the liver and brain. Not found in the muscle.

翻译后修饰

Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme.

亚细胞定位

Cytosol. Extracellular region or secreted. Nucleus.

UNIPROT

SwissProt: P18669 Human

SwissProt: Q9DBJ1 Mouse

SwissProt: P25113 Rat

别名