COMP Rabbit Polyclonal Antibody
Catalog# ER1906-53
COMP Rabbit Polyclonal Antibody
-
WB
-
Human
概述
产品名称
COMP Rabbit Polyclonal Antibody
抗体类型
Rabbit Polyclonal Antibody
免疫原
KLH conjugated synthetic peptide derived from human COMP 221-320/757
种属反应性
Human
验证应用
WB
分子量
83 KDa
阳性对照
Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.
偶联
unconjugated
产品特性
形态
Liquid
存放说明
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
存储缓冲液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
WB
-
1:500-2000
靶点
功能
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
背景文献
暂无
亚细胞定位
Secreted, extracellular space, extracellular matrix.
UNIPROT
别名
cartilage oligomeric matrix protein (pseudoachondroplasia
epiphyseal dysplasia 1
multiple) antibody
Cartilage oligomeric matrix protein antibody
Cartilage oligomeric matrix protein precursor antibody
COMP antibody
COMP_HUMAN antibody
EDM 1 antibody
EDM1 antibody
EPD 1 antibody
展开图片
-
Protein: Raji lysate;
Primary: rabbit Anti-COMP (ER1906-53) at 1:300;
Secondary: HRP conjugated Goat-Anti-rabbit IgG at 1: 5000;
Predicted band size: 83 kD
Observed band size: 77 kD
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Alternative Products
COMP Mouse Monoclonal Antibody [A10H2]
Application: WB,IHC-P
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
同靶点 & 同通路的产品