IL-17A Rabbit Polyclonal Antibody

功能

Interleukin 17A (IL-17 or IL-17A) is a pro-inflammatory cytokine. This cytokine is produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL-23. Originally, Th17 was identified in 1993 by Rouvier et al. who isolated IL17 transcript from a rodent T-cell hybridoma. The protein encoded by IL17A is a founding member of IL-17 family (see below). IL17 protein exhibits a high homology with a viral IL-17-like protein encoded in the genome of T-lymphotropic rhadinovirus Herpesvirus saimiri.[2] In rodents, IL-17 is often referred to as CTLA8.The biologically active IL-17 interacts with type I cell surface receptor IL-17R. In turn, there are at least three variants of IL-17R referred to as IL17RA, IL17RB, and IL17RC. After binding to the receptor, IL-17 activates several signalling cascades that, in turn, lead to the induction of chemokines. Acting as chemoattractants, these chemokines recruit the immune cells, such as monocytes and neutrophils to the site of inflammation. Typically, the signaling events mentioned above follow an invasion of the body by pathogens. Promoting the inflammation, IL-17 acts in concert with tumor necrosis factor and interleukin-1.Moreover, an activation of IL-17 signalling is often observed in the pathogenesis of various autoimmune disorders, such as psoriasis.

背景文献

1. Fossiez F.et.al.T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.J. Exp. Med. 183:2593-2603(1996).

序列相似性

Belongs to the IL-17 family.

组织特异性

Restricted to activated memory T-cells.

翻译后修饰

Found both in glycosylated and nonglycosylated forms.

亚细胞定位

Secreted.

UNIPROT

SwissProt: Q62386 Mouse

别名