Human Serum Albumin Mouse Monoclonal Antibody [8-A3]

功能

HSA is the most common protein in serum. It is produced in the liver and the concentration in serum is 35-50 mg/ml. HSA consists of a single polypeptide chain of 584 aminoacids, stabilized by 17 disulfide bridges. HSA is often used as a carrier molecule because of its binding capacity, and thus mainly functions as the regulator of the colloidal osmotic pressure of the blood. HSA binds a wide variety of hydrophobic ligands including fatty acids, bilirubin, thyroxine and hemin.

背景文献

1. MINGETTIPP,RUFFNER DE,KUANG wJ,et a1．Molecular strutture of the human albumin gene is revealed by nucleotide sequence within ql 1-22 of chromosome 4 [J]．J Biol Chem,1986,261:6747．6757

2. LAWN RM,ADEMAL J,BOCK SC,et a1．The sequence of human serum albumin cDNA and its expression in E．coli[J]．Nucleic Acids Res．1981,9(22):6103—6l14

3. SUGIO S,KASHIMA A,MOCHIZUK S,et a1．Crystal structure of human serum albumin at 2．5 A。resolution[J]．Protein Eng,1999,12:439．446

序列相似性

Belongs to the ALB/AFP/VDB family.

组织特异性

Plasma.

翻译后修饰

Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.; Glycated in diabetic patients.; Phosphorylated by FAM20C in the extracellular medium.; Acetylated on Lys-223 by acetylsalicylic acid.

亚细胞定位

Secreted

UNIPROT

SwissProt: P02768 Human

别名