WNT3A/WNT3 Goat Polyclonal Antibody

功能

The Wnt gene family encodes secreted signaling molecules that bind to frizzled receptors and influence oncogenesis and developmental processes, including regulation of cell fate and patterning during embryogenesis. The Wnt family has two functional classes according to their biological activities; Wnts that signal through a Wnt-1/wingless pathway by stabilizing cytoplasmic β-catenin, and Wnts that stimulate intracellular Ca2+ release and activate two kinases, CamKII and PKC, in a G protein-dependent manner. Wnt-3 is present during development of the cerebellum and is restricted to the Purkinje cell layer in the adult. In motoneurons, Wnt-3 is a retrograde signal that controls terminal branching of muscle afferents. Human Wnt-3 is 98% homologous to mouse Wnt-3 protein and 84% homologous to human Wnt-3a protein. The human Wnt-3 gene clusters with the Wnt-15 gene at chromosome 17q21.31.

背景文献

1. Zhan, L., et al. 2012. Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic. Biol. Med. 53: 758-768.

2. David, M.D., et al. 2010. Wnt-3a and Wnt-3 differently stimulate proliferation and neurogenesis of spinal neural precursors and promote neurite outgrowth by canonical signaling. J. Neurosci. Res. 88: 3011-3023.

亚细胞定位

Secreted

UNIPROT #

P56703

别名