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Anti-UGGT1 antibody

兔多抗 | 货号: HA500025


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价格:RMB   2500
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  • 概述

  • 产品描述 UGGT is part of the ER quality control system of glycoprotein folding and its activity increases the potential for correctly folded glycoproteins.The main proteins involved in the ER quality control system are UGGT, the ER lectin chaperones (calnexin and calreticulin), and glucosidase II. UGGT first recognizes the incompletely folded glycoprotein and monoglucosylates it. The lectins, calnexin and calreticulin, have high affinities for monoglucosylated proteins and the ER chaperones that associate with these lectins assist the folding of the misfolded glycoprotein. Subsequently, glucosidase II will deglucosylate the glycoprotein. If the glycoprotein is still misfolded, UGGT will re-glucosylate it and allow it to go through the cycle again.
  • 产品名称 Anti-UGGT1 antibody
  • 分子量 177 kDa
  • 种属反应性 Human,Mouse,Rat
  • 验证应用 WB,IHC-P
  • 抗体类型 兔多抗
  • 免疫原 Recombinant protein within human UGGT1 aa 1350-1555.
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein affinity purified.
  • 亚细胞定位 Endoplasmic reticulum.
  • 数据链接 SwissProt: Q9NYU2 Human
    SwissProt: Q6P5E4 Mouse
    SwissProt: Q9JLA3 Rat
  • 其它名称
    • GT antibody
    • HUGT1 antibody
    • UDP glucose glycoprotein glucosyltransferase 1 antibody
  • 应用

    WB: 1:500-1:1,000
    IHC-P: 1:50-1:200

  • 背景文献

  • 1. Arnold S.M. et. al. Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. Biochemistry 39:2149-2163(2000).
  • Publishing research using Anti-UGGT1 antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols