您的当前位置: 首页 > 产品 > 产品详情 > ET1606-36

Anti-PI 3 Kinase catalytic subunit alpha Recombinant Rabbit Monoclonal Antibody [SJ0186]

重组兔单抗 | 货号: ET1606-36


规格:

价格:RMB   1500
现在订购,【少量现货】
相关产品:

暂无,点击查看热门产品

  • 概述

  • 产品描述 Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others. Plays a role in the positive regulation of phagocytosis and pinocytosis.
  • 产品名称 Anti-PI 3 Kinase catalytic subunit alpha Recombinant Rabbit Monoclonal Antibody [SJ0186]
  • 分子量 Predicted band size: 124 kDa
  • 种属反应性 Human, Mouse
  • 验证应用 WB,IF-Cell,IF-Tissue,IP,IHC-P
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within Human PIK3CA aa 1,001-1,050 / 1,068.
  • 偶联 Non-conjugated
  • RRID AB_3069733
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cytosol, plasma membrane, cytoplasm, lamellipodium, membrane, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA.
  • 数据链接 SwissProt: P42336 Human
    SwissProt: Q8BTI9 Mouse
  • 其它名称
    • 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha antibody
    • 5-bisphosphate 3-kinase catalytic subunit alpha isoform antibody
    • caPI3K antibody
  • 应用

    WB: 1:1,000
    IF-Cell: 1:50-1:200
    IF-Tissue: 1:50-1:200
    IP: Use at an assay dependent concentration.
    IHC-P: 1:50-1:200

  • 背景文献

  • 1. Salm, F. et al. 2015. The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma. PloS one. 10: e0123958.

    2. Akula, M.K. et al. 2016. Control of the innate immune response by the mevalonate pathway. Nature immunology. 17: 922-9.
  • Publishing research using Anti-PI 3 Kinase catalytic subunit alpha Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

  • PMID:
    36865499
    Identification and Validation of FGF-Related Prognostic Signatures in Prostate Cancer Author: Ye, Y., Mo, R., Zheng, R., Zou, J., Liu, S., Mi, Q., & Zhong, W. Published: 2023 Application: IHC Species: Human Journal: Dis Markers IF: 3.464

Choose your product,application and species below,then click "Submit".

On the next page you can complete and submit your review.

  • * Code No.
  • *Application
  • *Sample
  • Species Tested
  • Against
  • Choose text
  • Content

Leave us a review

Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols