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Osterix Rabbit Polyclonal Antibody

RMB: 1500

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Catalog# ER1914-47

Osterix Rabbit Polyclonal Antibody

Application

  • WB

  • ELISA

Reactivity

  • Human

  • Mouse

This product has been cited in peer reviewed publications, see list HERE

概述

产品名称

Osterix Rabbit Polyclonal Antibody

抗体类型

Rabbit Polyclonal Antibody

免疫原

KLH conjugated synthetic peptide derived from human Osterix 331-431/431

种属反应性

Human, Mouse

验证应用

WB, ELISA

分子量

45 KDa

阳性对照

Osteoblast/chondrocyte specific.

偶联

unconjugated

产品特性

形态

Liquid

浓度

1ug/ul

存放说明

Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.

存储缓冲液

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

亚型

IgG

纯化方式

Protein A affinity purified.

应用稀释度

  • WB

  • 1:500-2000

  • ELISA

  • 1:5000-10000

靶点

功能

Transcription factor Sp7, also called Osterix (Osx), is a protein that in humans is encoded by the SP7 gene. It is a member of the Sp family of zinc-finger transcription factors [5] It is highly conserved among bone-forming verterbrate species. It plays a major role, along with Runx2 and Dlx5 in driving the differentiation of mesenchymal precursor cells into osteoblasts and eventually osteocytes. Sp7 also plays a regulatory role by inhibiting chondrocyte differentiation maintaining the balance between differentiation of mesenchymal precursor cells into ossified bone or cartilage. Mutations of this gene have been associated with multiple dysfunctional bone phenotypes in vertebrates. During development, a mouse embryo model with Sp7 expression knocked out had no formation of bone tissue. Through the use of GWAS studies, the Sp7 locus in humans has been strongly associated with bone mass density. [10] In addition there is significant genetic evidence for its role in diseases such as Osteoge nesis imperfecta (OI). In a developing organism, Sp7 serves as one of the most important regulatory shepherds for bone formation. Outside of the context of development, in adult mice ablation of Sp7 led to a lack of new bone formation, highly irregular cartilage accumulation beneath the growth plate and defects in osteocyte maturation and functionality.

背景文献

暂无

亚细胞定位

Nucleus.

UNIPROT #

SwissProt: Q8TDD2 Human

别名

MGC126598 antibody

Osterix antibody

Osx antibody

Sp 7 antibody

SP7 antibody

Sp7 transcription factor antibody

SP7_HUMAN antibody

Transcription factor Sp7 antibody

Zinc finger protein osterix antibody

图片

  • Sample:<br /> Embryo(Mouse) lysate at 30ug; <br /> Embryo(Mouse) lysate at 30ug; <br /> Primary: Anti-Osterix (<a href="/products/ER1914-47" style="font-weight: bold;text-decoration: underline;">ER1914-47</a>) at 1:200 dilution; <br /> Secondary: HRP conjugated Goat Anti-Rabbit IgG(bs-0295G-HRP) at 1: 3000 dilution; <br /> Predicted band size : 45kD<br /> Observed band size : 45kD<br />

    Sample:
    Embryo(Mouse) lysate at 30ug;
    Embryo(Mouse) lysate at 30ug;
    Primary: Anti-Osterix (ER1914-47) at 1:200 dilution;
    Secondary: HRP conjugated Goat Anti-Rabbit IgG(bs-0295G-HRP) at 1: 3000 dilution;
    Predicted band size : 45kD
    Observed band size : 45kD

  • Sample:Spinal cord (Mouse) Lysate at 40 ug<br /> Primary: Anti-Osterix(ER1914-47)at 1/300 dilution<br /> Secondary: Goat Anti-Rabbit IgG at 1/20000 dilution<br /> Predicted band size: 45kD<br /> Observed band size: 50kD<br />

    Sample:Spinal cord (Mouse) Lysate at 40 ug
    Primary: Anti-Osterix(ER1914-47)at 1/300 dilution
    Secondary: Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 45kD
    Observed band size: 50kD

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

引文

Filter:
  1. IHC
  2. WB
  3. IF

Alternative Products

metafield image

Sp7 / Osterix Recombinant Rabbit Monoclonal Antibody [PSH07-29]

Application: WB,IHC-P,IF-Tissue,IHC-Fr

Reactivity: Human,Mouse,Rat

Conjugate: unconjugated

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