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iFluor™ 488 Conjugated Anti-Iba1 Recombinant Rabbit Monoclonal Antibody [JM36-62]

重组兔单抗 | 货号: HA720158F


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价格:RMB   3280
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  • 概述

  • 产品描述 Ionized calcium-binding adapter molecule 1 (Iba1), also known as allograft inflammatory factor-1 (AIF-1), is a 147 amino acid cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. Iba1, containing two EF domains, is induced by cytokines and interferons. In an unstimulated state, Iba1 colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding Iba1 maps to chromosome 6p21.33 and resides in the tumor necrosis factor (TNF) cluster of genes located in the region represented by the human major histocompatibility complex (MHC).
  • 产品名称 iFluor™ 488 Conjugated Anti-Iba1 Recombinant Rabbit Monoclonal Antibody [JM36-62]
  • 分子量 Predicted band size: 17 kDa
  • 种属反应性 Human,Mouse,Rat
  • 验证应用 IF-Cell,FC
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within N-terminal human Iba1.
  • 偶联 iFluor™ 488
  • RRID AB_3072096
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cytoskeleton, ruffle membrane, phagocytic cup.
  • 数据链接 SwissProt: P55008 Human
    SwissProt: O70200 Mouse
    SwissProt: P55009 Rat
  • 其它名称
    • AIF 1 antibody
    • AIF-1 antibody
    • Aif1 antibody
  • 应用

    IF-Cell: 1:100-1:250
    FC: 1:500-1:1,000

  • 背景文献

  • 1. Hennessy E et al. Systemic TNF-a produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration. Brain Behav Immun 59:233-244 (2017).

    2. Arentsen T et al. The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior. Mol Psychiatry 22:257-266 (2017).
  • Publishing research using iFluor™ 488 Conjugated Anti-Iba1 Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols