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pathology_IHC antibody

Anti-PAX5 Recombinant Rabbit Monoclonal Antibody [JJ08-87]

重组兔单抗 | 货号: ET1701-49


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价格:RMB   1500
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  • 概述

  • 产品描述 The Pax family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. Pax family genes are also involved in a variety of signal transduction pathways in the adult organism. Mutations in Pax proteins have been linked to disease and cancer in humans. For example, the human PAX5 gene encodes a B cell lineage-specific protein, Pax-5, also designated B cell specific activator protein or BSAP, which is expressed in pro-B, pre-B and mature B lymphocytes but not in plasma cells. Pax-5 functions to regulate not only B cell development, but also influences the balance between immunoglobulin secretion and B cell proliferation. Overexpression of Pax-5 has been implicated in cellular transformation, and in the case of small lymphocytic lymphomas with plasmacytoid differentiation, a t(9;14)(p13;q32) translocation resulting in the deregulation of PAX5 gene expression has been detected.
  • 产品名称 Anti-PAX5 Recombinant Rabbit Monoclonal Antibody [JJ08-87]
  • 分子量 Predicted band size: 42 kDa
  • 种属反应性 Human, Mouse
  • 验证应用 WB,IF-Cell,IF-Tissue,IHC-P,FC
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within human PAX5 aa 240-280.
  • 偶联 Non-conjugated
  • RRID AB_3070216
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Nucleus.
  • 数据链接 SwissProt: Q02548 Human
    SwissProt: Q02650 Mouse
  • 其它名称
    • B cell lineage specific activator antibody
    • B cell lineage specific activator protein antibody
    • B cell specific activator protein antibody
  • 应用

    WB: 1:5,000
    IF-Cell: 1:50-1:200
    IF-Tissue: 1:50-1:200
    IHC-P: 1:400-1:1,000
    FC: 1:50-1:100

  • 背景文献

  • 1. Zhao L et al. Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering -catenin signalling and GADD45G expression. J Cell Mol Med 20:842-54 (2016).

    2. Ren Y et al. Diagnostic utility of PAX2 and PAX5 in distinguishing non-small cell lung cancer from small cell lung cancer. Int J Clin Exp Pathol 8:14709-16 (2015).
  • Publishing research using Anti-PAX5 Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols