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Anti-NLRP3 Recombinant Rabbit Monoclonal Antibody [SC06-23]

重组兔单抗 | 货号: ET1610-93


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  • 概述

  • 产品描述 NLRP3 is expressed predominantly in macrophages and as a component of the inflammasome, detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NLRP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated with a number of organ specific autoimmune diseases. NLRP3 is a component of the innate immune system that functions as a pattern recognition receptor (PRR) that recognizes pathogen-associated molecular patterns (PAMPs). NLRP3 belongs to the NOD-like receptor (NLR) subfamily of PRRs and NLRP3 together with the adaptor ASC protein PYCARD forms a caspase-1 activating complex known as the NLRP3 inflammasome. NLRP3 in the absence of activating signal is kept in an inactive state complexed with HSP90 and SGT1 in the cytoplasm. NLRP3 inflammasome detects danger signals such as crystalline uric acid and extracellular ATP released by damaged cells. These signals release HSP90 and SGT1 from and recruit ASC protein and caspase-1 to the inflammasome complex. Caspase-1 within the activated NLRP3 inflammasome complex in turn activates the inflammatory cytokine, IL-1β. The NLRP3 inflammasome appears to be activated by changes in intracellular potassium caused by potassium efflux from mechanosensitive ion channels located in the cell membrane
  • 产品名称 Anti-NLRP3 Recombinant Rabbit Monoclonal Antibody [SC06-23]
  • 分子量 Predicted band size: 118 kDa
  • 种属反应性 Human,Mouse,Rat
  • 验证应用 WB,IF-Cell,IHC-P,FC
  • 抗体类型 重组兔单抗
  • 免疫原 Recombinant protein within Human NLRP3 aa 5-161 / 1036.
  • 偶联 Non-conjugated
  • RRID AB_3069980
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cytoplasm, Inflammasome, Secreted, Nucleus, Endoplasmic reticulum.
  • 数据链接 SwissProt: Q96P20 Human
    SwissProt: Q8R4B8 Mouse
    Entrez Gene: 287362 Rat
  • 其它名称
    • AGTAVPRL antibody
    • AII/AVP antibody
    • Angiotensin/vasopressin receptor AII/AVP like antibody
  • 应用

    WB: 1:500-1:1,000
    IF-Cell: 1:100-1:500
    IHC-P: 1:50-1:400
    FC: 1:50-1:100

  • 背景文献

  • 1. Qiao J et al. Busulfan and cyclosphamide induce liver inflammation through NLRP3 activation in mice after hematopoietic stem cell transplantation. Sci Rep 5:17828 (2015).

    2. Ataide MA et al. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog 10:e1003885 (2014).
  • Publishing research using Anti-NLRP3 Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

  • PMID:
    37243164
    CVB3 Inhibits NLRP3 Inflammasome Activation by Suppressing NF-κB Pathway and ROS Production in LPS-Induced Macrophages Author: Wang, Y., Sun, Z., Zhang, H., Song, Y., Wang, Y., Xu, W., & Li, M. Published: 2023 Application: WB Species: Mouse Journal: Viruses. IF: 5.818
  • PMID:
    37182445
    Small molecule inhibitor CRT0066101 inhibits cytokine storm syndrome in a mouse model of lung injury Author: Cui, B., Liu, Y., Chen, J., Chen, H., Feng, Y., & Zhang, P. Published: 2023 Application: WB,IF Species: Mouse Journal: Int Immunopharmacol IF: 5.714
  • PMID:
    37783713
    Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions Author: Shah, W., Zhao, Q., Wang, S., Zhang, M., Ma, H., Guan, Y., Zhang, Y., Liu, Y., Zhu, C., Wang, S., Zhang, X., Dong, J., & Ma, H. Published: 2023 Application: WB Species: Rat Journal: Sci Rep IF: 4.6
  • PMID:
    37021049
    Chrysin ameliorates synovitis and fibrosis of osteoarthritic fibroblast-like synoviocytes in rats through PERK/TXNIP/NLRP3 signaling Author: Ding, L., Liao, T., Yang, N., Wei, Y., Xing, R., Wu, P., Li, X., Mao, J., & Wang, P. Published: 2023 Application: WB,IF-Cell Species: Rat Journal: Front Pharmacol IF: 5.988
  • PMID:
    37183293
    Functionalized Metal-Organic Framework-Modified Hydrogel That Breaks the Vicious Cycle of Inflammation and ROS for Repairing of Diabetic Bone Defects Author: Lao, A., Wu, J., Li, D., Shen, A., Li, Y., Zhuang, Y., Lin, K., Wu, J., & Liu, J. Published: 2023 Application: WB,IF Species: Rat Journal: Small IF: 15.153
  • PMID:
    36456961
    Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome Author: Zheng, X., Gong, T., Tang, C., Zhong, Y., Shi, L., Fang, X., Chen, D., & Zhu, Z. Published: 2022 Application: WB Species: Rat Journal: BMC Anesthesiol. IF: 2.376
  • PMID:
    36466156
    Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis Author: Xin, Y., Wang, W., Mao, E., Yang, H., & Li, S. Published: 2022 Application: IHC,WB Species: Rat Journal: Mediators Inflamm. IF: 4.529
  • PMID:
    36076588
    Oxytocin ameliorates high glucose- and ischemia/reperfusion-induced myocardial injury by suppressing pyroptosis via AMPK signaling pathway Author: Yao, M., Wang, Z., Jiang, L., Wang, L., Yang, Y., Wang, Q., Qian, X., Zeng, W., Yang, W., Liang, R., & Qian, J. Published: 2022 Application: WB Species: Rat Journal: Biomed Pharmacother. IF: 7.419
  • PMID:
    37052047
    Lactobacillus plantarum postbiotics trigger AMPK-dependent autophagy to suppress Salmonella intracellular infection and NLRP3 inflammasome activation Author: Wu, Y., Hu, A., Shu, X., Huang, W., Zhang, R., Xu, Y., & Yang, C. Published: 2022 Application: WB Species: Pig Journal: J Cell Physiol . IF: 6.513
  • PMID:
    36338340
    Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals Author: Jiang, H., Chen, F., Song, D., Zhou, X., Ren, L., & Zeng, M. Published: 2022 Application: WB Species: Mouse Journal: Oxid Med Cell Longev. IF: 7.310
  • PMID:
    33549727
    Microglial TLR4-induced TAK1 phosphorylation and NLRP3 activation mediates neuroinflammation and contributes to chronic morphine-induced antinociceptive tolerance. Pharmacological research, 165, 105482. Author: Wang, H., Huang, M., Wang, W., Zhang, Y., Ma, X., Luo, L., Xu, X., Xu, L., Shi, H., Xu, Y., Wang, A., & Xu, T. Published: 2021 Application: WB Species: Mouse Journal: Pharmacol Res IF: 5.57
  • PMID:
    34912499
    Protective Effects of the Soluble Receptor for Advanced Glycation End-Products on Pyroptosis during Myocardial Ischemia-Reperfusion Author: Liu, Y., Guo, X., Zhang, J., Han, X., Wang, H., Du, F., Zeng, X., & Guo, C. Published: 2021 Application: IHC Species: Mouse Journal: Oxid Med Cell Longev IF: 6.543
  • PMID:
    33061523
    Spinal TLR4/P2X7 Receptor-Dependent NLRP3 Inflammasome Activation Contributes to the Development of Tolerance to Morphine-Induced Antinociception Author: Tao Xu;Aizhong Wang Published: 2020 Application: WB Species: mice Journal: Journal of Inflammation Research IF: 3.174
  • PMID:
    33019975
    Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm Author: Zhang, X., Li, F., Wang, W., Ji, L., Sun, B., Xiao, X., Wang, X., Chen, Y., Liu, B., Ye, W., Tian, C., Wang, H., & Zheng, Y. Published: 2020 Journal: Biochem Biophys Res Commun. IF: 3.575
  • PMID:
    31071330
    AT-533,a Hsp90 inhibitor,attenuates HSV-1-induced inflammation. Author: Kai Zheng,Yifei Wang Published: 2019 Application: WB,CO-IP Species: BV2 cells Journal: Biochem Pharmacol. IF: 4.825
  • PMID:
    31250434
    The effect of NLRP inflammasome on the regulation of AGEs‐ induced inflammatory response in human periodontal ligament cells Author: Dingming Huang ; Lan Zhang Published: 2019 Application: WB Species: Human periodontal ligament cells Journal: J Periodontal Res. IF: 2.613

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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