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Anti-NF-κB p65 Recombinant Rabbit Monoclonal Antibody [SZ10-04]

重组兔单抗 | 货号: ET1603-12


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  • 概述

  • 产品描述 Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NF kB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp kB sequence in the immunoglobulin k light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFkB is activated and NFkB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.
  • 产品名称 Anti-NF-κB p65 Recombinant Rabbit Monoclonal Antibody [SZ10-04]
  • 分子量 Predicted band size: 65 kDa
  • 种属反应性 Human,Mouse
  • 验证应用 WB,IF-Cell,IF-Tissue,IHC-P,IP,FC
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within human NF-kB p65 aa 490-540.
  • 偶联 Non-conjugated
  • RRID AB_3069668
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Nucleus, Cytoplasm.
  • 数据链接 SwissProt: Q04206 Human
    SwissProt: Q04207 Mouse
  • 其它名称
    • Avian reticuloendotheliosis viral (v rel) oncogene homolog A antibody
    • MGC131774 antibody
    • NF kappa B p65delta3 antibody
  • 应用

    WB: 1:1,000-1:5,000
    IF-Cell: 1:50-1:200
    IF-Tissue: 1:50-1:200
    IHC-P: 1:50-1:200
    FC: 1:2,000
    IP: Use at an assay dependent concentration.

  • 背景文献

  • 1. Kang K et al. Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa. Sci Rep 6:22632 (2016).

    2. Kropp KA et al. A temporal gate for viral enhancers to co-opt Toll-like-receptor transcriptional activation pathways upon acute infection. PLoS Pathog 11:e1004737 (2015).
  • Publishing research using Anti-NF-κB p65 Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

  • PMID:
    37024790
    Experimental study on the effect of luteolin on the proliferation, apoptosis and expression of inflammation-related mediators in lipopolysaccharide-induced keratinocytes Author: Wang, X., Yao, Y., Li, Y., Guo, S., Li, Y., & Zhang, G. Published: 2023 Application: WB Species: Human Journal: Int J Immunopathol Pharmacol IF: 3.298
  • PMID:
    35115492
    TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models Author: Wu, J., Feng, Z., Chen, L., Li, Y., Bian, H., Geng, J., Zheng, Z. H., Fu, X., Pei, Z., Qin, Y., Yang, L., Zhao, Y., Wang, K., Chen, R., He, Q., Nan, G., Jiang, X., Chen, Z. N., & Zhu, P. Published: 2022 Application: WB Species: Mouse Journal: Nat Commun IF: 14.919
  • PMID:
    35266845
    TRAF6 autophagic degradation by avibirnavirus VP3 inhibits antiviral innate immunity via blocking NFKB/NF-κB activation Author: Deng, T., Hu, B., Wang, X., Ding, S., Lin, L., Yan, Y., Peng, X., Zheng, X., Liao, M., Jin, Y., Dong, W., Gu, J., & Zhou, J. Published: 2022 Application: WB Species: Chicken Journal: Autophagy IF: 16.016
  • PMID:
    35651980
    BRAFV600E Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT Author: Gao, Y., Xiang, D., Li, W., Zheng, X., Wang, L., Li, Z., & Chen, T. Published: 2022 Application: WB Journal: Front Endocrinol (Lausanne). IF: 5.555
  • PMID:
    35538475
    N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma Author: Chen, Y., Lu, Z., Qi, C., Yu, C., Li, Y., Huan, W., Wang, R., Luo, W., Shen, D., Ding, L., Ren, L., Xie, H., Xue, D., Wang, M., Ni, K., Xia, L., Qian, J., & Li, G. Published: 2022 Application: WB Species: Human Journal: Mol Cancer. IF: 41.444
  • PMID:
    33716743
    Ginsenoside Rb1 Alleviates Alcohol-Induced Liver Injury by Inhibiting Steatosis, Oxidative Stress, and Inflammation. Frontiers in pharmacology, 12, 616409. Author: Lai, Y., Tan, Q., Xv, S., Huang, S., Wang, Y., Li, Y., Zeng, T., Mo, C., Chen, Y., Huang, S., Zhou, C., Gao, L., & Lv, Z. Published: 2021 Application: IHC,IF Species: Zebrafish Journal: Front Pharmacol IF: 5.81
  • PMID:
    34051663
    Autophagy was activated against the damages of placentas caused by nano-copper oral exposure. Ecotoxicology and environmental safety, 220, 112364. Advance online publication. Author: Kang, M., Luo, J., Zhao, L., Shi, F., Ye, G., He, X., Hao, S., Yang, D., Chen, H., Guo, H., Li, Y., & Tang, H. Published: 2021 Application: WB Species: Rat Journal: Ecotoxicology and Environmental Safety IF: 4.872
  • PMID:
    34707127
    Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling Author: Wang, J., Wang, J., Hong, W., Zhang, L., Song, L., Shi, Q., Shao, Y., Hao, G., Fang, C., Qiu, Y., Yang, L., Yang, Z., Wang, J., Cao, J., Yang, B., He, Q., & Weng, Q. Published: 2021 Application: WB Species: Mouse Journal: Nat Commun IF: 14.914
  • PMID:
    30818128
    Fusobacterium nucleatum stimulates monocyte adhesion to and transmigration through endothelial cells Author: Yafei Wu Published: 2019 Application: WB Species: HUVEC cell Journal: Arch Oral Biol. IF: 1.663
  • PMID:
    30396897
    Phosphothreonine Lyase Promotes p65 Degradation in a Mitogen-Activated Protein Kinase/Mitogen- and StressActivated Protein Kinase 1-Dependent Manner Author: Qin Liu Published: 2019 Application: WB Species: Escherichia coli Journal: Infection and Immunity IF: 3.256
  • PMID:
    30448447
    Astaxanthin protects lipopolysaccharide-induced inflammatory response in Channa argus through inhibiting NF-κB and MAPKs signaling pathways. Author: wangguiqing Published: 2018 Application: WB Species: Channa argus Journal: Fish Shellfish Immunol. IF: 3.185

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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