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iFluor™ 488 Conjugated Anti-Glucose Transporter GLUT1 Recombinant Rabbit Monoclonal Antibody [SA0377]

重组兔单抗 | 货号: HA720154F


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价格:RMB   3280
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  • 概述

  • 产品描述 Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. In adipose and muscle tissue, insulin stimulates a rapid and dramatic increase in glucose uptake, which is largely due to the redistribution of the insulin-inducible glucose transporter, Glut4. In response to insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane, where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane, and shows a much less dramatic translocation in response to insulin. Glut1 and Glut4 are twelve-pass transmembrane proteins (12TM) whose carboxy-termini may dictate their cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity.
  • 产品名称 iFluor™ 488 Conjugated Anti-Glucose Transporter GLUT1 Recombinant Rabbit Monoclonal Antibody [SA0377]
  • 分子量 Predicted band size: 54 kDa
  • 种属反应性 Human,Mouse, Rat
  • 验证应用 IF-Cell,IF-Tissue
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within Human GLUT1 aa 443-492 / 492.
  • 偶联 iFluor™ 488
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cell membrane, Melanosome
  • 数据链接 SwissProt: P11166 Human
    SwissProt: P17809 Mouse
    SwissProt: P11167 Rat
  • 其它名称
    • Choreoathetosis/spasticity episodic (paroxysmal choreoathetosis/spasticity) antibody
    • CSE antibody
    • DYT17 antibody
  • 应用

    IF-Cell: 1:100
    IF-Tissue: 1:50

  • 背景文献

  • 1. Boyer-Di Ponio J et al. Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes. PLoS One 9:e84179 (2014).

    2. Saucillo DC et al. Leptin metabolically licenses T cells for activation to link nutrition and immunity. J Immunol 192:136-44 (2014).
  • Publishing research using iFluor™ 488 Conjugated Anti-Glucose Transporter GLUT1 Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols