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Recombinant Mouse M-CSF Protein

蛋白质 | 货号:HA210276


规格:
价格:RMB   12500
  • Overview

  • Product name Recombinant Mouse M-CSF Protein
  • Catalog No. HA210276
  • Description
  • Bio-Activity The ED50 for this effect is typically 0.5-3ng/ml
  • Endotoxin <0.01 EU/ug of the protein.
  • Background

    Macrophage colony-stimulating factor ( M-CSF), is a secreted cytokine which influences hematopoietic stem cells to differentiate into macrophages or other related cell types. M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumor cell cytotoxicity. M-CSF released by osteoblasts (as a result of endocrine stimulation by parathyroid hormone) exerts paracrine effects on osteoclasts. . Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. (See colony-stimulating factor.). M-CSF binds to receptors on osteoclasts inducing differentiation, and ultimately leading to increased plasma calcium levels—through the resorption (breakdown) of bone. Additionally, high levels of CSF-1 expression are observed in the endometrial epithelium of the pregnant uterus as well as high levels of its receptor CSF1R in the placental trophoblast. Studies have shown that activation of trophoblastic CSF1R by local high levels of CSF-1 is essential for normal embryonic implantation and placental development. More recently, it was discovered that CSF-1 and its receptor CSF1R are implicated in the mammary gland during normal development and neoplastic growth.

  • Product Information

  • Tag No tag
  • Usage guide

  • Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. • 12 months from date of receipt, -20 to -80°C as supplied. • 2 month, 2 to 8°C under sterile conditions after reconstitution. • 1 year, -70°C under sterile conditions after reconstitutions.
  • Reconstitution 2ug/ml in sterile culture condition medium.
  • Publishing research using Recombinant Mouse M-CSF Protein? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols