• 概述

• 产品描述 Myc gene encodes for a transcription factor that is believed to regulate expression of 15% of all genes through binding on Enhancer Box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. This c-Myc antibody detects endogenous levels of total c-Myc protein and is also for detection of Myc-tagged fusion proteins.
• 产品名称 Anti-C-myc antibody
• 分子量 57 kDa
• 种属反应性 Human
• 验证应用 WB
• 抗体类型 兔多抗
• 免疫原 Synthetic peptide.
• 偶联 Non-conjugated

• 性能

• 形态 Liquid
• 浓度 1 mg/mL.
• 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型 IgG
• 纯化方式 Immunogen affinity purified.
• 亚细胞定位 Cell nuclear.
• 数据链接 SwissProt: P01106 Human
  
• 其它名称
  • AU016757 antibody
  • Avian myelocytomatosis viral oncogene homolog antibody
  • bHLHe39 antibody
  • c Myc antibody
  • Class E basic helix-loop-helix protein 39 antibody
  • MRTL antibody
  • Myc antibody
  • Myc protein antibody
  • Myc proto oncogene protein antibody
  • Myc proto-oncogene protein antibody
  • myc-related translation/localization regulatory factor antibody
  • MYC_HUMAN antibody
  • Myc2 antibody
  • MYCC antibody
  • Myelocytomatosis oncogene antibody
  • Niard antibody
  • Nird antibody
  • Oncogene Myc antibody
  • OTTHUMP00000158589 antibody
  • Proto-oncogene c-Myc antibody
  • Protooncogene homologous to myelocytomatosis virus antibody
  • RNCMYC antibody
  • Transcription factor p64 antibody
  • Transcriptional regulator Myc-A antibody
  • V-Myc avian myelocytomatosis viral oncogene homolog antibody
  • v-myc myelocytomatosis viral oncogene homolog (avian) antibody
  more

• 应用

  WB: 1:500

• 

  Fig1: Western blot analysis on myc-tagged recombinant protein (A) and A549 cell lysates (B).

• 背景文献

• 1. "A quantitative atlas of mitotic phosphorylation."Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008)
  
  2. "Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62."Gupta S., Seth A., Davis R.J. Proc. Natl. Acad. Sci. U.S.A. 90:3216-3220(1993)

• Publishing research using Anti-C-myc antibody? Please let us know so that we can cite the reference in this datasheet.

• PMID:
  35269427 Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting β-Catenin Degradation Author: Bai, Q., Yang, X., Li, Q., Chen, W., Tian, H., Lian, R., Liu, X., Wang, S., & Yang, Y. Published: 2022 Application: IHC Species: Mouse Journal: Cells IF: 6.600
• PMID:
  33995089 Case Report: 7-Ethyl-10-Hydroxycamptothecin, a DNA Topoisomerase I Inhibitor, Performs BRD4 Inhibitory Activity and Inhibits Human Leukemic Cell Growth. Frontiers in pharmacology, 12, 664176. Author: Wang, A., Li, L., Li, M., Wang, S., & Wang, C. Published: 2021 Application: WB Species: Human Journal: Frontiers in Pharmacology IF: 4.4
• PMID:
  30471730 MORF2 tightly associates with MORF9 to regulate chloroplast RNA editing in Arabidopsis. Author: Zhong-Nan Yang Published: 2019 Application: WB Species: Arabidopsis Journal: Plant Sci. IF: 3.712
• PMID:
  29942288 The ColRS-Regulated Membrane Protein Gene XAC1347 Is Involved in Copper Homeostasis and hrp Gene Expression in Xanthomonas citri subsp. citri Author: Huasong Zou Published: 2018 Application: WB Species: Xanthomonas citri subsp. citri (Xcc) Journal: Front Microbiol IF: 4.019
• PMID:
  28491824 Rabies Virus Infection Induces Microtubule Depolymerization to Facilitate Viral RNA Synthesis by Upregulating HDAC6 Author: Min Liao and Ji-Yong Zhou Published: 2017 Application: WB Species: Rabies Virus Journal: Front Cell Infect Microbiol IF: 4.3

Choose your product,application and species below,then click "Submit".

On the next page you can complete and submit your review.

Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.