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Anti-IRF7 antibody [SC0617]

重组兔单抗 | 货号: ET1610-89


规格:
价格:RMB   2500
  • 概述

  • 产品描述 Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-α and β) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-α and interferon-β genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7 and IFN consensus sequence-binding protein (ICSBP).
  • 产品名称 Anti-IRF7 antibody [SC0617]
  • 分子量 54 kDa
  • 种属反应性 Human,Mouse,Rat,Zebrafish
  • 验证应用 WB,ICC/IF,IHC,IP,FC
  • 抗体类型 重组兔单抗
  • 免疫原 recombinant protein
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A purified.
  • 亚细胞定位 Nucleus, Cytoplasm.
  • 数据链接 Q92985 Human
    P70434 Mouse
    Unigene: 101159 Rat
  • 其它名称 IMD39 antibody
    Interferon regulatory factor 7 antibody
    Interferon regulatory factor 7H antibody
    IRF 7 antibody
    IRF 7A antibody
    IRF 7H antibody
    IRF-7 antibody
    IRF7 antibody
    IRF7_HUMAN antibody
    IRF7A antibody
    IRF7B antibody
    IRF7C antibody
    IRF7H antibody
  • 应用

    WB: 1:1,000-1:2,000
    ICC: 1:100-1:500
    IHC: 1:50-1:200
    FC: 1:50-1:100

  • 背景文献

  • 1. Zhang Y et al. Hantaan virus infection induces CXCL10 expression through TLR3, RIG-I, and MDA-5 pathways correlated with the disease severity. Mediators Inflamm 2014:697837 (2014).
    2. de Verteuil DA et al. Immunoproteasomes shape the transcriptome and regulate the function of dendritic cells. J Immunol 193:1121-32 (2014).
  • Publishing research using Anti-IRF7 antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols