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Anti-Adiponectin receptor protein 1 antibody [SC69-04]

重组兔单抗 | 货号: ET1610-86


规格:
价格:RMB   2500
  • 概述

  • 产品描述 Adiponectin is a circulating hormone secreted by adipocytes that improves the metabolism of glucose and lipids, and is expressed at low levels in those with obesity and diabetes. Adiponectin receptors AdipoR1 and AdipoR2, also designated progestin and adipoQ receptor family members I and II, respectively, regulate fatty acid oxidation and the uptake of glucose by adiponectin. Each receptor activates a unique set of signaling molecules including AMPK, p38 MAPK and PPARα. AdipoR1 has a high-affinity for globular adiponectin and low-affinity for full-length adiponectin, while AdipoR2 has an intermediate affinity for both forms. AdipoR1 and AdipoR2 are mainly expressed in liver and muscle. Adiponectin, AdipoR1 and AdipoR2 are all associated with body composition, Insulin sensitivity, and metabolic parameters. Physical training increases circulating adiponectin and mRNA expression of AdipoR1 and AdipoR2 in muscle, which may mediate the improvement of Insulin resistance and the metabolic syndrome in response to exercise.
  • 产品名称 Anti-Adiponectin receptor protein 1 antibody [SC69-04]
  • 分子量 43 kDa
  • 种属反应性 Human,Mouse,Rat,Zebrafish
  • 验证应用 WB,ICC/IF,IHC,FC
  • 抗体类型 重组兔单抗
  • 免疫原 recombinant protein
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A purified.
  • 亚细胞定位 Cell membrane.
  • 数据链接 Q96A54 Human
    Q91VH1 Mouse
    Unigene: 104556 Rat
  • 其它名称 ACDCR1 antibody
    ADIPO R1 antibody
    Adiponectin receptor protein 1 antibody
    ADIPOR 1 antibody
    Adipor1 antibody
    ADR1_HUMAN antibody
    CGI 45 antibody
    CGI 45 protein antibody
    CGI-45 antibody
    CGI45 antibody
    CGI45 protein antibody
    FLJ25385 antibody
    FLJ42464 antibody
    PAQR1 antibody
    Progestin and adipoQ receptor family member I antibody
    TESBP1A antibody
  • 应用

    WB: 1:1,000-1:5,000
    ICC: 1:50-1:200
    IHC: 1:50-1:200
    FC: 1:50-1:100

  • 背景文献

  • 1. Fang F et al. Adiponectin attenuates angiotensin II-induced oxidative stress in renal tubular cells through AMPK and cAMP-Epac signal transduction pathways. Am J Physiol Renal Physiol 304:F1366-74 (2013).
    2. Gulli RA et al. Exercise restores insulin, but not adiponectin, response in skeletal muscle of high-fat fed rodents. Am J Physiol Regul Integr Comp Physiol 303:R1062-70 (2012).
  • Publishing research using Anti-Adiponectin receptor protein 1 antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols