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Anti-Desmin antibody [SI18-00]

重组兔单抗 | 货号: ET1606-30


规格:
价格:RMB   2500
  • 概述

  • 产品描述 Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Desmin makes up attachments between the terminal Z-disc and membrane-associated proteins to form a force-transmitting system. Mutations in the gene encoding for Desmin are associated with adult-onset skeletal myopathy, sporadic disease and mild cardiac involvement.
  • 产品名称 Anti-Desmin antibody [SI18-00]
  • 分子量 53 kDa
  • 种属反应性 Human,Mouse,Rat,Zebrafish
  • 验证应用 WB,ICC/IF,IHC,FC
  • 抗体类型 重组兔单抗
  • 免疫原 recombinant protein
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A purified.
  • 亚细胞定位 Cytoplasm, Cell membrane.
  • 数据链接 P17661 Human
    P31001 Mouse
    P48675 Rat
  • 其它名称 CMD1I antibody
    CSM1 antibody
    CSM2 antibody
    DES antibody
    DESM_HUMAN antibody
    Desmin antibody
    FLJ12025 antibody
    FLJ39719 antibody
    FLJ41013 antibody
    FLJ41793 antibody
    Intermediate filament protein antibody
    OTTHUMP00000064865 antibody
  • 应用

    WB: 1:1,000-1:5,000
    ICC: 1:50-1:200
    IHC: 1:50-1:200
    FC: 1:50-1:100

  • 背景文献

  • 1. Yousef H et al. Systemic attenuation of the TGF pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. Oncotarget 6:11959-78 (2015).
    2. von Renesse A et al. POMK mutation in a family with congenital muscular dystrophy with merosin deficiency, hypomyelination, mild hearing deficit and intellectual disability. J Med Genet 51:275-82 (2014).
  • Publishing research using Anti-Desmin antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols