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Anti-β-Catenin antibody

兔多抗 | 货号: 0407-16


规格:
价格:RMB   2100
  • 概述

  • 产品描述 β-Catenin is a multifunctional adaptor protein involved in cadherin-mediated cell–cell adhesion and in responding to the activation of several signal transduction pathways. CK1 phosphorylates β-catenin on Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37 and Thr41.). Mutations in β-Catenin have been implicated in its accumulation and various forms of carcinomas.
  • 产品名称 Anti-β-Catenin antibody
  • 分子量 86 kDa
  • 种属反应性 Human,Mouse,Rat,Zebrafish
  • 验证应用 WB,ICC,IHC
  • 抗体类型 兔多抗
  • 免疫原 peptide
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Immunogen affinity purified
  • 亚细胞定位 Cell membrane, perinuclear region
  • 数据链接 Q02248
  • 其它名称 Beta catenin antibody
    Beta-catenin antibody
    Cadherin associated protein antibody
    Catenin (cadherin associated protein), beta 1, 88kDa antibody
    Catenin beta 1 antibody
    Catenin beta-1 antibody
    CATNB antibody
    CHBCAT antibody
    CTNB1_HUMAN antibody
    CTNNB antibody
    CTNNB1 antibody
    DKFZp686D02253 antibody
    FLJ25606 antibody
    FLJ37923 antibody
    OTTHUMP00000162082 antibody
    OTTHUMP00000165222 antibody
    OTTHUMP00000165223 antibody
    OTTHUMP00000209288 antibody
    OTTHUMP00000209289 antibody
  • 应用

    WB 1:5,000
    ICC: 1:200

  • 背景文献

  • 1. Kikuchi A.;"Regulation of beta-catenin signaling in the Wnt pathway."; Biochem. Biophys. Res. Commun. 268:243-248(2000).
    2. Dobrosotskaya I.Y., James G.L.; "MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures."; Biochem. Biophys. Res. Commun. 270:903-909(2000).
    3. Kim J.-S., Crooks H., Dracheva T., Nishanian T.G., Singh B., Jen J., Waldman T.; "Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells."; Cancer Res. 62:2744-2748(2002).
  • Publishing research using Anti-β-Catenin antibody? Please let us know so that we can cite the reference in this datasheet.

  • Zhu, X., Wang, W., Zhang, X., Bai, J., Chen, G., Li, L., & Li, M. (2015). All-Trans Retinoic Acid-Induced Deficiency of the Wnt/beta-Catenin Pathway Enhances Hepatic Carcinoma Stem Cell Differentiation. PLoS One, 10(11), e0143255. PMID:26571119
  • Xiang, B., Chen, L., Wang, X., Zhao, Y., Wang, Y., & Xiang, C. (2017). Transplantation of Menstrual Blood-Derived Mesenchymal Stem Cells Promotes the Repair of LPS-Induced Acute Lung Injury. Int J Mol Sci, 18(4). PMID:28346367

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols