The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Anti-Cleaved-Lamin A (D230) antibody
Human, Mouse, Rat
The antiserum was produced against synthesized peptide derived from human Lamin A. AA range:181-230
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Immunogen affinity purified.
SwissProt: P02545 Human
LMNA antibody; LMN1 antibody; Prelamin-A/C antibody;
Fig1: Western Blot analysis of various cells using Cleaved-Lamin A (D230) Polyclonal Antibody
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