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Anti-NM23 antibody [12A1]

小鼠单抗 | 货号: EM1801-20


规格:
价格:RMB   2500
  • 概述

  • 产品描述 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
  • 产品名称 Anti-NM23 antibody [12A1]
  • 分子量 17/19 kDa
  • 种属反应性 Human
  • 验证应用 WB,ICC,IHC
  • 抗体类型 小鼠单抗
  • 免疫原 Synthetic peptide within human NM23 aa 80-120.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 2 mg/ml.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG1
  • 纯化方式 Protein G purified.
  • 亚细胞定位 Cytoplasm, Nucleus.
  • 数据链接 SwissProt: P15531 Human
  • 其它名称 AWD antibody
    AWD, drosophila, homolog of antibody
    GAAD antibody
    Granzyme A activated DNase antibody
    Granzyme A-activated DNase antibody
    GZMA activated DNase antibody
    Metastasis inhibition factor NM23 antibody
    NB antibody
    NBS antibody
    NDK A antibody
    NDKA antibody
    NDKA_HUMAN antibody
    NDP kinase A antibody
    NDPK-A antibody
    NDPKA antibody
    NM23 antibody
    NM23 long variant, included antibody
    nm23-H1 antibody
    NM23-M1 antibody
    NM23H1B, included antibody
    NME/NM23 nucleoside diphosphate kinase 1 antibody
    Nme1 antibody
    NME1-NME2 spliced read-through transcript, included antibody
    Non-metastatic cells 1, protein (NM23A) expressed in antibody
    Nonmetastatic cells 1, protein expressed in antibody
    Nonmetastatic protein 23 antibody
    Nonmetastatic protein 23, homolog 1 antibody
    Nucleoside diphosphate kinase A antibody
    Tumor metastatic process-associated protein antibody
  • 应用

    WB:1:500-1:2,000
    ICC:1:50-1:200
    IHC:1:50-1:200

  • 背景文献

  • 1. Chowdhury D. et al. The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol. Cell 23:133-142(2006).
    2. Fan Z. et al. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 112:659-672(2003).
  • Publishing research using Anti-NM23 antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols