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Anti-CD34 antibody

兔多抗 | 货号: 0108-2


规格:
价格:RMB   2100
  • 概述

  • 产品描述 CD34 is a heavily glycosylated type I transmembrane molecule, that can be phoshorylated by a variety of kinases including Protein kinase C and Tyrosine kinases. CD34 antigen is expressed on small vessel endothelial cells and tumors of epithelial origin. CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. So CD34 is considered to be ideal marker for identifying and quantifying hematopoietic progenitor stem cells. With interaction with CrkL, CD34 becomes a substrate for PKC and CD34 surface expression is associated with activation of PKC.
  • 产品名称 Anti-CD34 antibody
  • 分子量 90 kDa
  • 种属反应性 Human,Zebrafish
  • 验证应用 WB,ICC,IHC,FC
  • 抗体类型 兔多抗
  • 免疫原 peptide
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Immunogen affinity purified
  • 亚细胞定位 Cell membrane
  • 数据链接 P28906
  • 其它名称 CD34 antibody
    CD34 antigen antibody
    CD34 molecule antibody
    CD34_HUMAN antibody
    Cluster designation 34 antibody
    Hematopoietic progenitor cell antigen CD34 antibody
    HPCA1 antibody
    Mucosialin antibody
    OTTHUMP00000034733 antibody
    OTTHUMP00000034734 antibody
  • 应用

    WB: 1:500-1:1,000
    ICC: 1:100
    IHC: 1:3,000
    FC: 1:50-1:100

  • 背景文献

  • 1. Freund D., Wiebe G.J., Ehninger G., Corbeil D.; "Sequence analysis of the human CD34 antigen."; Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
    2. The MGC Project Team;"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
    3. Sutherland D.R., Watt S.M., Dowden G., Karhi K., Baker M.A., Greaves M.F., Smart J.E.;"Structural and partial amino acid sequence analysis of the human hemopoietic progenitor cell antigen CD34.";Leukemia 2:793-803(1988).
  • Publishing research using Anti-CD34 antibody? Please let us know so that we can cite the reference in this datasheet.

  • Gu, B., Zhang, J., Wu, Y., Zhang, X., Tan, Z., Lin, Y., . . . Zhang, M. (2011). Proteomic analyses reveal common promiscuous patterns of cell surface proteins on human embryonic stem cells and sperms. PLoS One, 6(5), e19386. PMID:21559292

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols